1812 NICARDIPINE VERSUS SALINE INJECTION AS TREATMENT FOR PEYRONIE'S DISEASE: A PROSPECTIVE, RANDOMIZED, SINGLE-BLIND TRIAL

Abstract

You have accessJournal of UrologySexual Function/Dysfunction/Andrology: Peyronie's Disease/Surgical Therapy1 Apr 20111812 NICARDIPINE VERSUS SALINE INJECTION AS TREATMENT FOR PEYRONIE'S DISEASE: A PROSPECTIVE, RANDOMIZED, SINGLE-BLIND TRIAL Jintetsu Soh, Yoshio Naya, Atsushi Ochiai, Yasuyuki Naitoh, Noriyuki Kanemitsu, Kazumi Kamoi, kawauchi Akihiro, and tsuneharu Miki Jintetsu SohJintetsu Soh Kyoto, Japan More articles by this author , Yoshio NayaYoshio Naya Kyoto, Japan More articles by this author , Atsushi OchiaiAtsushi Ochiai Kyoto, Japan More articles by this author , Yasuyuki NaitohYasuyuki Naitoh Kyoto, Japan More articles by this author , Noriyuki KanemitsuNoriyuki Kanemitsu Kyoto, Japan More articles by this author , Kazumi KamoiKazumi Kamoi Kyoto, Japan More articles by this author , kawauchi Akihirokawauchi Akihiro Kyoto, Japan More articles by this author , and tsuneharu Mikitsuneharu Miki Kyoto, Japan More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.2184AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Various conservative treatments for Peyronie's disease (PD) have been attempted over the years. Intra-lesional verapamil injection has been tested in prospective randomized studies, but the effect of this treatment seems insufficient. Nicardipine is a calcium antagonist alternative to verapamil and is reportedly more effective in vitro. The objective of our study was to evaluate the usefulness of intra-lesional nicardipine injection as a conservative treatment for PD in the transition period of acute and chronic phase. METHODS The subjects were assessed by IIEF-5 and international pain scale. The plaque size was measured by ultrasonography after 20 μg intra-cavernosal injection of alprostadil (prostaglandin E1). The penile curvature was also measured by taking a photograph at maximum rigidity. 86 patients (age: 38-72 years, mean: 52) were enrolled in this study. A total of 74 patients were assigned randomly to nicardipine group (10 mg diluted in 10 ml of distilled water daily, n=37) and control group (10 ml of saline water, n=37). A total of 6 injections were administrated biweekly. RESULTS A reduction of pain score was seen throughout the course of treatment in both groups with a significant difference between the nicardipine and control groups (MANOVA test, p=0.019). A significant improvement of IIEF-5 score occurred only in the nicardipine group at 48 weeks after the initiation of treatment (p<0.01). The plaque size was significantly reduced at 48 weeks only in the nicardipine group (12 points, p=0.0004 by paired t-test). The penile curvature was significantly improved in both groups (p<0.01) without significant difference between them (p=0.14). There were no severe side effects, such as hypotension or other cardiovascular events. CONCLUSIONS Our findings indicate that intra-lesional nicardipine injection is clinically effective as a conservative treatment for PD in the transition period of acute and chronic phase. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e727 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Jintetsu Soh Kyoto, Japan More articles by this author Yoshio Naya Kyoto, Japan More articles by this author Atsushi Ochiai Kyoto, Japan More articles by this author Yasuyuki Naitoh Kyoto, Japan More articles by this author Noriyuki Kanemitsu Kyoto, Japan More articles by this author Kazumi Kamoi Kyoto, Japan More articles by this author kawauchi Akihiro Kyoto, Japan More articles by this author tsuneharu Miki Kyoto, Japan More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...