Abstract
Polychlorinated biphenyls (PCB) 153 are a category of chlorinated aromatic hydrocarbon compounds manufactured for use in various commercial and industrial applications. PCBs are predominantly used as coolants and lubricants in electrical equipment, but is also utilized for the manufacturing of plastic and rubber products as well as pigments and dyes. As PCB and its metabolites have been recognized as potential health hazards, it is important for us to understand its implications on male fertility or the endocrine-related adverse effects associated with PCB exposure. We examined the effects of PCB 153 on serum testosterone levels as an independent variable, and in conjunction with other clinical, demographic and biochemical factors. We hypothesized that men with higher serum levels of PCB153 are associated with lower levels of testosterone, potentially suggesting the detrimental effects of PCB as an endocrine disruptor in humans. Using data collected from the 1999-2000 and 2001-2002 National Health and Nutrition Examination Survey (NHANES), we analyzed serum total testosterone and PCB153 levels, demographic data and comorbidities for men aged 18 years and older. Univariate and multivariate linear regression analysis was used to evaluate the association between total testosterone and serum PCB153.
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