1807P Pan-cancer analysis of SMARCA4 genomic alterations to reveal a complex molecular landscape

Abstract

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4), encoding a subunit of the ATPase subunit of the SWI/SNF chromatin-remodeling complex, is correlated with the chromatin remodeling. Previous studies revealed that functional loss mutations of SMARCA4 result in reduced cyclin D1 expression and selective sensitivity to CDK4/6 inhibitors. The differences in mutation profiles in pan-cancer can help understand pathogenesis, prognosis, and identify targets for therapy.