Abstract
High opening pressures (OP) are characteristic of HMD; a reduction in OP may indicate improvement in alveolar stability. Animals were delivered abdominally, and ventilated with either conventional or high frequency ventilators. The anesthetized, paralyzed animals were tested in a constant volume pressure plethysmograph with an esophageal balloon in place. The inspiratory limb of the pressure-volume curve was analyzed for OP defined as the pressure at the point of departure from an isovolumetric transpulmonary change. Peak Pressure (PP) was defined as the highest pressure required for ventilation. Mean values (±SD) obtained were: Analysis by ANOVA for repeated measures revealed a significant (P<0.01) improvement in OP by day one. Further changes in OP and changes in PP were not significant. Change in OP may be an early, sensitive measure of improvement in HMD.
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