Abstract
A greater than normal concentration of aldosterone has been found in adrenal tumors from patients with primary aldosteronism (1). 18-Hydroxycorticosterone is probably an intermediary product in the conversion of corticosterone to aldosterone (2). This conversion takes place in the zona glomerulosa. The parallel changes in secretion rates of aldosterone and 18-hydroxycorticosterone which have been observed in man under a variety of conditions support the intermediary role of 18-hydroxycorticosterone (3). However, 18-hydroxycorticosterone is also synthesized in the fasciculata-reticularis zones of the cow adrenal gland (4), and to a lesser degree, in the inner zones of the rat adrenal gland (5).The present report describes the conversion of corticosterone-4-14C to 18-hydroxycorticosterone and aldosterone by an aldosterone producing tumor and the surrounding nontumorous adrenal tissue. Only the mitochondrial fraction of both tissues contained converting activity. The tumor converted 4 times more corticostero...
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