Abstract
Tumorigenic CTCs express the chemokine receptor CXCR4 and CXCL12 attracts bone marrow cells and CXCR4+ cancer cells at metastatic sites. To isolate and characterize CTCs-CXCR4+ cells a CXCL12-loaded-hydrogel (CLG) using the Belotero® Hyaluronic gel dermal filler was developed. CLG should reproduce a “pseudo niche” attracting and trapping CTCs.
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Schedule a callMore From: Annals of oncology : official journal of the European Society for Medical Oncology
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