Abstract
Publisher Summary This chapter discusses cerebellar and deep brain stimulation in movement disorders. Implantable electrodes suitable for chronic electrical stimulation of the human brain have been developed in the past 15 years or so. In monkeys rendered spastic by bilateral ablation of the motor cortex, analysis of passive stretch responses has further shown that acute cerebellar stimulation does not simply reduce stretch response excitability. Recent experience with chronic stimulation of the dentate nucleus itself, using an implanted wire electrode, has shown clinical effects in a single case that were similar to those reported after successful surface stimulation. Biopsies taken at the time of implantation have suggested that the cerebellum is already abnormal in many of the patients before stimulation begins.
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