177Lu Effect of Geometry Factors in Radionuclide Calibrator

Abstract

The accuracy of radiopharmaceutical activity which will be administered to the patients is very important in nuclear medicine, especially in the case of therapeutical procedure. Hence, all safety aspects should be considered, including the standardization of the dose calibrator. From the reference, the accuracy of dose calibrator is influenced by various factors, such as the geometrical factors of the syringes or vials. The aim of this work was to investigate the effect of different container such as syringes and vials on the accuracy of dose calibrator. The initial work was done by preparing 5 cc glass ampoule and 1 cc syringes containing 177Lu. Both samples was measured using the Capintec CRC 7-BT dose calibrator. The ampoule and syringe activity was measured at the base of the chamber and 5 cm above the base of the chamber, respectively. The result shows that the correction factor was 2.5 % for the syringe and 1.03 % for the ampoule. The correction factor should be considered when the dose calibrator will be used for measuring the administered to the patient to get more accurate activity measurement and patient safety.