177 SAFETY, EFFICACY, AND HEALTH RELATED QUALITY OF LIFE OF AUTOLOGOUS MYOBLAST TRANSPLANTATION FOR TREATMENT OF URINARY INCONTINENCE IN CHILDREN WITH CLASSIC BLADDER EXSTROPHY: FOUR-YEAR FOLLOW-UP

Abstract

You have accessJournal of UrologyStem Cell Research1 Apr 2011177 SAFETY, EFFICACY, AND HEALTH RELATED QUALITY OF LIFE OF AUTOLOGOUS MYOBLAST TRANSPLANTATION FOR TREATMENT OF URINARY INCONTINENCE IN CHILDREN WITH CLASSIC BLADDER EXSTROPHY: FOUR-YEAR FOLLOW-UP Abdol-Mohammad Kajbafzadeh, Saman S. Talab, Ali Tourchi, and Azadeh Elmi Abdol-Mohammad KajbafzadehAbdol-Mohammad Kajbafzadeh Tehran, Iran More articles by this author , Saman S. TalabSaman S. Talab Tehran, Iran More articles by this author , Ali TourchiAli Tourchi Tehran, Iran More articles by this author , and Azadeh ElmiAzadeh Elmi Tehran, Iran More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.246AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES We have previously reported our preliminary results of transurethral autologous myoblast injection for structural urinary incontinence in children with bladder exstrophy. The results revealed that at 15.3 months 88%of the patients were socially dry. In the present study we aimed to evaluate the safety, health related quality of life, durability, and efficacy of transurethral autologous myoblast injection during 4 year follow up in the same cohort of patients. METHODS The study included 7 boys that underwent transurethral autologous myoblast injection between May and December 2006. All patients have persistent urinary incontinence after bladder neck reconstruction and bulking agent injections. Patients were followed 4 years after myoblast injection (clinical outcomes, cystometry, urodynamics, and uroflowmetry). Health related quality of life (HRQol) of patients before treatment and at final follow-up was measured according to the kid-KINDL and Kiddo-KINDL and KINDL for parent's questioners. RESULTS No evidence of urinary obstruction, inflammation, and development of hyperplasia has been reported in the patients. Among the patients 71.42% were completely continent and two patients (28.57%) were socially dry with complete daytime dryness. The HRQol showed significant improvement in the present follow-up. Urodynamic studies revealed a progressive increase in bladder capacity (p <0.001). Mean DLPP experienced a 152% increase in the four year follow-up (p <0.001). Of uroflowmetry parameters, average maximum flow rate (Qmax) improved significantly (p <0.001). CONCLUSIONS The four-year outcomes confirm that transurethral injection of myoblasts for urinary incontinence in children with bladder exstrophy is almost ambulatory, reliable, reproducible, with little morbidity, and effective. The present data support the conclusion that this new treatment modality could represent a valid, promising therapeutic approach in patients with structural urinary incontinence. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e73-e74 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Abdol-Mohammad Kajbafzadeh Tehran, Iran More articles by this author Saman S. Talab Tehran, Iran More articles by this author Ali Tourchi Tehran, Iran More articles by this author Azadeh Elmi Tehran, Iran More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...