1766P Urachal cancer: A population-based study of 315 cases in California from 1988-2019

Abstract

Urachal cancer is a rare genitourinary malignancy that is considered to be an aggressive cancer. There is a paucity of epidemiological data on this cancer. Adults aged 20 years and older diagnosed with urachal cancer between 1988 and 2019 were identified through the California Cancer Registry (n = 315). Cancer occurrence across various sociodemographic characteristics (e.g., age, sex, race/ethnicity, neighborhood socioeconomic status (SES)) as well as tumor characteristics, initial treatment and survival were examined via frequency and percentage distributions. Kaplan Meier methods were used to calculate overall survival. Males represented 56.5% (n = 178) of cases. The majority of cases were non-Hispanic Whites (60.3%) followed by Hispanic (18.4%), Asian/Pacific Islander (14.3%), and non-Hispanic Black (6.0%). Most cases were diagnosed at regional stage (37.8%) followed by localized (32.7%) and metastatic disease (27.0%). Urachal cancer was the cause of death in 32.4% of cases followed by other cause (22.5%) and unknown cause (3.5%); 41.6% of patients were alive. Median overall survival (OS) for all patients was 76 months (95% CI, 50-109). Median OS was 178 months in patients with in situ/localized disease, 83 months in patients with regional disease, and 19 months in patients with metastatic disease.Table: 1766PCharacteristics of adults aged 20 and older diagnosed with urachal cancer in California, 1988-2019N%Total315100SexMale17856.5%Female13743.5%Race/EthnicityNon-Hispanic White19060.3%Non-Hispanic Black196.0%Hispanic5818.4%Asian/Pacific Islander4514.3%American Indian/Other30.95%Stage at diagnosisLocalized10332.7%Regional11937.8%Metastatic8527.0%Unknown82.5% Open table in a new tab This is the largest known study of urachal cancer. Approximately one-third of patients had distant metastatic disease at the time of diagnosis. Patients with localized and regional disease lived longer than those with metastatic disease. The study’s findings provide new insight into the demographics and survival of this rare genitourinary malignancy.