Abstract
Cartilage 5′nucleotidase (5NT) activity has been implicated in calcium pryophosphate dihydrate (CPPD) deposition [Arthritis Rheum 24:492, 1981]. We measured synovial fluid (SF) 5NT and nucleotide pyrophosphohydrolase (NPPH), another cartilage ectoenzyme associated with CPPD deposition, in 173 patients with well-characterized arthropathies. A cytosolic enzyme, adenosine deaminase (ADA), and an ectoenzyme not associated with CPPD deposition, alkaline phosphatase (AP), were measured as controls.SF 5NT and NPPH activities are highest and ADA activities are lowest in joints with noninflammatory SF which contain calcium crystals (Wilcoxon rank-sum, p<0.05). SF activities correspond with those reported in cartilage and suggest a specific association of elevated SF 5NT and NPPH activities with articular calcium crystal deposition.
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