Abstract
Studies with animal surfactant preparations have shown dramatic improvements in oxygenation without concomitant changes in dynamic compliance. The present study deals with the effects of a purely synthetic surfactant (E) upon arterial blood gases (ABG) and compliance (Crs)/resistance (Rrs), determined by the recently introduced single breath occlusion technique. Six premature babies with HMD, enrolled in the European OSIRIS trial were studied. Crs/Rrs and ABG were determined 30 min. before and after E administration and repeated at 24 h intervals. Results: Pre- and post values (means) are given for the 1st and 2nd dose. Measurements 3 and 4 are follow-ups. *p<0.05 vs. previous value. Conclusion: E fails to induce an acute amelioration of lung mechanics and gas exchange, later improvements in oxygenation parallel those seen in Crs. The lack of immediate effect of E may be due to the absence of surfactant-associated proteins in this preparation.
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