176-LB: Long-Term Glycemic Variability in Diabetic Patients According to Their Glycemic Control in Follow-Up

Abstract

Long term glycemic variability is linked to a higher rate of chronic complications and mortality in diabetic population and is also regarded a synonymous of poor glycemic control. However, the relationship between glycemic variability and glycemic control has not been studied properly. Aims to describe differences in glycemic variability in diabetic patients according to their trends in glucose level during follow-up. Methods from our database we selected those patients identified as diabetic (fasting glucose ≥ 126 mg/dl and/or Hba1c≥ 6.5%) who attended to our laboratory from January 2010 to august 2016 for a simultaneous Hba1c and glucose determinations. From the whole sample we selected those with at least 3 Hba1c determinations for 2 years. In all cases mean (M), standard deviation (SD) and variation coefficient (VC) were calculated from Hba1c during follow-up. Patients were categorized in four groups according to their first (i) and last determination (f) of Hba1c: group 1: i and f < 7%, group 2: i < 7% and f > 7%, group 3: i > 7% and f < 7% and group 4 i and f > 7%. We compared between groups VC. Results we studied results from 1589 patients (men 52%, age 60.95 (SD 14.83) years, mean number of determinations: 6.65 (95% CI 6.39-6.84). The percent of patients in group 1 to 4 respectively were : 22.7%, 10.2%, 23.5% and 43.6% . The mean (SD) Hba1c i and f were for group 1: 6.33% (0.41), 6.26% (0.43), group 2: 6.30% (0.55), 8.71% (1.99) , group 3: 8.96% (2.01), 6.23% (0.49) and group 4: 9.4% (2.01), 8.78% (1.71) . Mean VC (SD) were from group 1 to 4: 9.16(9.53), 18.36(11.17), 18.37(11.41), 12.68(8.09))(p <0.05 groups 1 vs. 2,3 and 4, group 2 vs. 1, 4, group 3 vs. 1 and 4, group 4 vs. 1, 2 and 3, P NS group 2 vs. 3). Conclusions: long term glycemic variability measured by VC is very similar in groups that migrates from their original glycemic level, no matter if their final Hba1c is within the goal. High VC is not necessarily related to poor metabolic control. Disclosure H. Garcia-Alcala: None.