Abstract
High fat diet (HFD) leads to disrupted striatal dopamine function and alterations in fat preference. One mechanism by which this occurs is depletion of gut lipid messengers, including oleoylethanolamine (OEA), which when replenished rescues dopamine response and increases preference for low fat emulsions via the generation of vagal afferent signals (Tellez et al., 2013). Using a supplement containing the OEA precurser N-oleyl-phosphatidylethanolamine and epigallocatechin-3-gallate (NOPE+EGCG), we tested whether this effect translates to humans and whether supplementation improves outcomes on a behavioral weight loss trial.
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