174 Defining the composition and function of Lamin ribonuclear bodies during keratinocyte terminal differentiation and nuclear degradation

Abstract

Keratinocyte cornification and epidermal barrier formation are tightly controlled processes, requiring degradation of organelles, including the nucleus. However, the underlying molecular mechanisms are not well defined. We have identified the myosin II-mediated dispersal of an internal fragment of Lamin A (LMNA) during end-stage terminal differentiation prior to nuclear degradation. non-membrane-bound LMNA bodies were distinct from keratohyalin granules and lamellar bodies and associated both with RNA and with components of the nuclear envelope.