1738 PERFORMANCE OF FREE PSA MASS IN ESTIMATION OF PROSTATE VOLUME IN JAPANESE MEN WITH BENIGN PROSTATE HYPERPLASIA

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You have accessJournal of UrologyBenign Prostatic Hyperplasia: Epidemiology and Natural History/Evaluation and Markers1 Apr 20121738 PERFORMANCE OF FREE PSA MASS IN ESTIMATION OF PROSTATE VOLUME IN JAPANESE MEN WITH BENIGN PROSTATE HYPERPLASIA Hitoshi Masuda, Yasukazu Nakanishi, Satoru Kawakami, Kazutaka Saito, Fumitaka Koga, Noboru Numao, Yoh Matsuoka, Junichirou Ishioka, Minato Yokoyama, Yasuhisa Fujii, and Kazunori Kihara Hitoshi MasudaHitoshi Masuda Tokyo, Japan More articles by this author , Yasukazu NakanishiYasukazu Nakanishi Tokyo, Japan More articles by this author , Satoru KawakamiSatoru Kawakami Tokyo, Japan More articles by this author , Kazutaka SaitoKazutaka Saito Tokyo, Japan More articles by this author , Fumitaka KogaFumitaka Koga Tokyo, Japan More articles by this author , Noboru NumaoNoboru Numao Tokyo, Japan More articles by this author , Yoh MatsuokaYoh Matsuoka Tokyo, Japan More articles by this author , Junichirou IshiokaJunichirou Ishioka Tokyo, Japan More articles by this author , Minato YokoyamaMinato Yokoyama Tokyo, Japan More articles by this author , Yasuhisa FujiiYasuhisa Fujii Tokyo, Japan More articles by this author , and Kazunori KiharaKazunori Kihara Tokyo, Japan More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.1699AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Recently, free prostate-specific antigen (PSA) (fPSA) has been reported to outperform PSA at estimating total prostate volume (TPV) in both Western and Asian populations. Obese patients with benign prostate hyperplasia (BPH) may have lower free PSA as well as PSA due to hemodilution. Lower fPSA may falsely affect estimation of TPV. The aim of this study was to determine fPSA mass as the absolute amount of fPSA protein secreted into circulation, and to evaluate its usefulness in the prediction of TPV. METHODS Subjects were 1788 men with PSA up to 10 ng/ml, including 1657 men who underwent a transrectal ultrasound (TRUS)-guided extended prostate biopsy and were proven to have BPH. Body surface area (BSA), plasma volume, PSA mass and fPSA mass were estimated by means of the following established formulae: BSA (m2) = body weight (kg)0.425 × height (m)0.72 × 0.007184, plasma volume (L) = BSA (m2) × 1.670, PSA mass (μg) = serum PSA (ng/ml) × plasma volume (L) and fPSA mass (μg) = serum fPSA (ng/ml) × plasma volume (L). The association between PSA, PSA mass, fPSA or fPSA mass and TRUS-measured TPV were evaluated by Pearson′s correlation coefficient (γ), linear regression analyses and receiver operating characteristic (ROC) curves. RESULTS Both PSA and fPSA had significant and positive associations with age and TPV with significant and negative associations with plasma volume. fPSA showed a strongest and significant correlation with TPV, followed by fPSA, PSA mass and PSA with γ of 0.52, 0.50, 0.28 and 0.26. The ROC curves showed that fPSA mass (area under the curve [(AUC] = 0.795) outperformed fPSA (AUC = 0.780), PSA mass (AUC = 0.707) or PSA (AUC = 0.690) did at estimating TPV cutoff values of 30 ml. CONCLUSIONS This is the first study showing the performance of fPSA mass at estimating TPV. It may be helpful to use fPSA mass in predicting the likelihood of BPH. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e700-e701 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Hitoshi Masuda Tokyo, Japan More articles by this author Yasukazu Nakanishi Tokyo, Japan More articles by this author Satoru Kawakami Tokyo, Japan More articles by this author Kazutaka Saito Tokyo, Japan More articles by this author Fumitaka Koga Tokyo, Japan More articles by this author Noboru Numao Tokyo, Japan More articles by this author Yoh Matsuoka Tokyo, Japan More articles by this author Junichirou Ishioka Tokyo, Japan More articles by this author Minato Yokoyama Tokyo, Japan More articles by this author Yasuhisa Fujii Tokyo, Japan More articles by this author Kazunori Kihara Tokyo, Japan More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...