Abstract
The most sensitive stage of mammalian embryonic development to the lethal effects of X-irradiation is during the preimplantation period. As little as 10 rads has increased the resorption rate in pregnant rats exposed to irradiation on the first day of gestation. In order to determine whether other known teratogenic agents also affect the embryo in the pre-implantation period, pregnant rats were exposed to acetylsalicylic acid (200; 400 mg/kg) on the first day of gestation: Acetylsalicylic acid is a known teratogen when administered to the pregnant rat during early organogenesis. The results indicated that the preimplantation embryo was also adversely affected by aspirin exposure. Since ethyl alcohol was used as the carrier, separate experiments were carried out in pregnant rats using three exposures of ethyl alcohol (2.5 g; 5.0 and 10 g/kg). Both aspirin and ethyl alcohol produced an increase in embryonic death when pregnant rats were exposed to these agents on the first day of gestation. It appears that some toxic agents known to be embryotoxic during organogenesis can cause embryonic death during the preimplantation period. (HD 630; HD 7075; HD 11038)
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