1726 BODY MASS INDEX IN YOUNG MEN IS ASSOCIATED WITH PROSTATE ENLARGEMENT LATER IN LIFE

Abstract

You have accessJournal of UrologyBenign Prostatic Hyperplasia: Epidemiology and Natural History/Evaluation and Markers1 Apr 20111726 BODY MASS INDEX IN YOUNG MEN IS ASSOCIATED WITH PROSTATE ENLARGEMENT LATER IN LIFE John Eifler, Stacy Loeb, Luigi Ferrucci, H. Ballentine Carter, and E. Jeffrey Metter John EiflerJohn Eifler Baltimore, MD More articles by this author , Stacy LoebStacy Loeb Baltimore, MD More articles by this author , Luigi FerrucciLuigi Ferrucci Baltimore, MD More articles by this author , H. Ballentine CarterH. Ballentine Carter Baltimore, MD More articles by this author , and E. Jeffrey MetterE. Jeffrey Metter Baltimore, MD More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.1997AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Recent data from the National Health and Nutrition Examination Survey (NHANES) suggests that the prevalence of obesity among young adult men in the United States is increasing. Many studies have demonstrated the association between body mass index (BMI) and prostate enlargement. However, little is known about the relationship of obesity at a young age and prostate size later in life. METHODS Total prostate volume was determined by pelvic magnetic resonance imaging (MRI) for participants in the Baltimore Longitudinal Study of Aging (BLSA). From this population, we identified 80 men with BMI measurements available before 40 years of age with MRI-determined prostate volume after 60 years of age. Logistic regression was used to determine the association between BMI at an early age with later development of prostate enlargement (prostate volume > 40 cc). RESULTS In the study population, the median BMI was 24.9 and median duration of follow up was 32.9 years. At age ≥ 60 years, the median prostate volume was 33.5 mL. A logistic regression model controlling for age established that an elevated BMI at an early age was significantly associated with prostatic enlargement at a later age (OR 1.26 for categorical variable, p = 0.0056). In a model including both BMI at an early age (i.e. less than 40 years old) and BMI at a later age (i.e. greater than 60 years), early BMI approached significance (OR 1.21, p = 0.08), whereas BMI at the time of MRI had no statistically significant association with prostatic enlargement (OR 1.04, p = 0.57). An examination of different age ranges demonstrated the greatest relationship between BMI and prostate size when BMI was measured at a young age (Figure 1). CONCLUSIONS These results suggest that young men with elevated BMI are more likely to develop an enlarged prostate later in life. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e693 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information John Eifler Baltimore, MD More articles by this author Stacy Loeb Baltimore, MD More articles by this author Luigi Ferrucci Baltimore, MD More articles by this author H. Ballentine Carter Baltimore, MD More articles by this author E. Jeffrey Metter Baltimore, MD More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...