1724 INITIAL PSA >= 1.5 NG/ML IN MEN =< 50 YEARS OLD PREDICTS A SUBSEQUENT HIGHER RISK OF PROSTATE CANCER

Abstract

You have accessJournal of UrologyProstate Cancer: Detection and Screening I1 Apr 20101724 INITIAL PSA >= 1.5 NG/ML IN MEN =< 50 YEARS OLD PREDICTS A SUBSEQUENT HIGHER RISK OF PROSTATE CANCER Matthew Uhlman, Ping Tang, Leon Sun, Cary Robertson, Thomas Polascik, David Albala, Craig Donatucci, and Judd Moul Matthew UhlmanMatthew Uhlman More articles by this author , Ping TangPing Tang More articles by this author , Leon SunLeon Sun More articles by this author , Cary RobertsonCary Robertson More articles by this author , Thomas PolascikThomas Polascik More articles by this author , David AlbalaDavid Albala More articles by this author , Craig DonatucciCraig Donatucci More articles by this author , and Judd MoulJudd Moul More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.02.1572AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Studies have shown that an initial PSA higher than the median in young men predicts a subsequent higher risk of prostate cancer (PCa). No study has examined this relationship when patients are stratified by race. METHODS A cohort of 3,530 African American (AA) men and 6,118 Caucasian American (CA) men =< 50 years old and with a PSA < 4 ng/ml at their first PSA screening was retrieved from the Duke Prostate Center database. Patients were divided into groups based on their initial PSA (0.1-0.6, 0.7-1.4, 1.5-2.4 and 2.5- 4.0 ng/ml). Univariate and age-adjusted multivariate logistic regression were used to estimate the relative risk of cancer in these PSA groups. The incidences of PCa during subsequent periods of follow up were calculated RESULTS The median PSA for both AA and CA men was 0.7 ng/ml at age =< 50 years old. The incidence of PCa was not significant different between PSA < 0.6 ng/ml and 0.7-1.4 groups for either AA or CA men. AA and CA men with an initial PSA in the 1.5-2.4 ng/ml range had a 9.3- and 6.7-fold increase in age-adjusted relative risk of PCa, respectively. After a follow-up of up to 9 years, an initial PSA >= 1.5 ng/ml was associated with gradually increased detection rates during periods of follow-up in both AA and CA men. CONCLUSIONS Using an initial PSA cutoff of 1.5 ng/ml may be better than a median PSA (0.7 ng/ml) to determine the risk of PCa in both AA and CA men =< 50 years old. Durham, NC© 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 183Issue 4SApril 2010Page: e666 Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.MetricsAuthor Information Matthew Uhlman More articles by this author Ping Tang More articles by this author Leon Sun More articles by this author Cary Robertson More articles by this author Thomas Polascik More articles by this author David Albala More articles by this author Craig Donatucci More articles by this author Judd Moul More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...