1722 ASSOCIATIONS BETWEEN MODEST WEIGHT LOSS AND ONSET AND PROGRESSION OF LOWER URINARY TRACT SYMPTOMS

Abstract

You have accessJournal of UrologyBenign Prostatic Hyperplasia: Epidemiology and Natural History/Evaluation and Markers1 Apr 20111722 ASSOCIATIONS BETWEEN MODEST WEIGHT LOSS AND ONSET AND PROGRESSION OF LOWER URINARY TRACT SYMPTOMS Jennifer St. Sauver, Aruna Sarma, John Hollingsworth, Debra Jacobson, Michaela McGree, Rodney Dunn, Michael Lieber, and Steven Jacobsen Jennifer St. SauverJennifer St. Sauver Mayo Clinic, MN More articles by this author , Aruna SarmaAruna Sarma Ann Arbor, MI More articles by this author , John HollingsworthJohn Hollingsworth Ann Arbor, MI More articles by this author , Debra JacobsonDebra Jacobson Mayo Clinic, MN More articles by this author , Michaela McGreeMichaela McGree Mayo Clinic, MN More articles by this author , Rodney DunnRodney Dunn Ann Arbor, MI More articles by this author , Michael LieberMichael Lieber Mayo Clinic, MN More articles by this author , and Steven JacobsenSteven Jacobsen Pasadena, CA More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.1993AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Obesity has been associated with lower urinary tract symptoms (LUTS) in aging men, and weight loss has been proposed as a means to reduce or prevent LUTS. To test this hypothesis, we used information collected in two prospective cohort studies to determine if weight loss was associated with a decreased risk of developing moderate to severe LUTS in black and white men. METHODS The study population consisted of white men participating in the Natural History of Prostatism: The Olmsted County Study (OCS) and black men participating in the Flint Men's Health Study (FMHS). Change in weight between base-line and four years of follow-up was classified into three categories: no weight loss, loss of some weight (<5% of base-line weight), or loss of at least 5% of base-line weight. Corresponding changes in American Urological Association Symptom Index (AUASI) score over the four years of follow-up were characterized and compared across weight loss categories. In OCS men, Cox proportional hazards models were used to estimate the associations between weight loss and development of adverse outcomes, adjusting for potential confounders including baseline age, weight, diabetes, hypertension and exercise. RESULTS Weight loss was not associated with LUTS progression in black or white men (Table). Additionally, the rate at which AUASI scores changed did not vary by categories of weight loss (OCS p value=0.70; FMHS p value=0.54). Finally, in the OCS cohort, weight loss was not associated with risk of developing a moderate to severe AUASI score (>7) or receipt of treatment for benign prostatic hyperplasia or LUTS (all p values>0.05). Outcome No weight loss (N%) Lost < 5% of baseline weight Lost ⊗ of baseline weight (N%) Chi-square p value OCS No change in symptoms 170(13.34) 33(12.13) 10(7.81) 0.22 Decrease in symptoms 470(36.89) 111(40.81) 45(35.16) Increase in symptoms 634(49.76) 128(47.06) 73(57.03) FMHS No change in symptoms 9(9.78) 8(15.09) 2(10.53) 0.75 Decrease in symptoms 45(48.91) 24(45.28) 7(36.84) Increase in symptoms 38(41.30) 21(39.62) 10(52.63) CONCLUSIONS Modest weight loss may not prevent the onset or progression of LUTS in aging men. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e691-e692 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Jennifer St. Sauver Mayo Clinic, MN More articles by this author Aruna Sarma Ann Arbor, MI More articles by this author John Hollingsworth Ann Arbor, MI More articles by this author Debra Jacobson Mayo Clinic, MN More articles by this author Michaela McGree Mayo Clinic, MN More articles by this author Rodney Dunn Ann Arbor, MI More articles by this author Michael Lieber Mayo Clinic, MN More articles by this author Steven Jacobsen Pasadena, CA More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...