Abstract
growth of PC3/sh-4E-BP1 tumors in nude mice was significantly faster than that of PC3/C tumors. Administration of docetaxel induced the growth inhibition of both PC3/C and PC3/sh-4E-BP1 tumors; however, the growth inhibitory effect of docetaxel on PC3/C tumors was more marked than that on PC3/sh-4E-BP1 tumors. CONCLUSIONS: These findings suggest that 4E-BP1 plays an important role in the growth as well as resistance to proapoptotic therapeutic stimuli in CRPC cells through the regulation of major molecules mediating the signal transduction and apoptosis.
Published Version
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