Abstract
Virus-like particles (VLP) have been known for several years to be a promising alternative to the existing viral and non-viral DNA delivery systems. VLPs are self-assembled structures composed only of proteins necessary for capsid formation and DNA packaging. They are replication deficient and exhibit a similar morphology and cell tropism compared to their viral origin. One of the major differences between VLPs and traditional viral vectors is the way of DNA packaging. For viral delivery systems the use of packaging cell lines is indispensable whereas the DNA packaging into the VLP can be accomplished by controlled and reproducible in vitro methods.
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