Abstract
Late cornified envelope (LCE) proteins are small cationic epidermal proteins with antimicrobial properties, and the combined deletion of LCE3B and LCE3C genes is a risk factor for psoriasis that affects skin microbiome composition. In a yeast two-hybrid screen we identified cysteine-rich tail 1 protein (CYSRT1) as an interacting partner of members of all LCE groups except LCE6. These interactions were confirmed in a mammalian cell system by co-immunoprecipitation. CYSRT1 is a highly conserved protein of unknown function that we found to be specifically expressed in cutaneous and oral epithelia, and which colocalizes with LCE3 proteins in the upper layers of the suprabasal epidermis.
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