Abstract
Late cornified envelope (LCE) proteins are small cationic epidermal proteins with antimicrobial properties, and the combined deletion of LCE3B and LCE3C genes is a risk factor for psoriasis that affects skin microbiome composition. In a yeast two-hybrid screen we identified cysteine-rich tail 1 protein (CYSRT1) as an interacting partner of members of all LCE groups except LCE6. These interactions were confirmed in a mammalian cell system by co-immunoprecipitation. CYSRT1 is a highly conserved protein of unknown function that we found to be specifically expressed in cutaneous and oral epithelia, and which colocalizes with LCE3 proteins in the upper layers of the suprabasal epidermis.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.