Abstract
SMARCA4 (also known as BRG1) and SMARCB1 are proteins with transcription-regulation through helicase and ATPase activity in the SWI/SNF chromatin-remodelling complex. Alterations in these genes have been described as prognostic and related to tumor differentiation and metastasis. Inactivation has a role in the development, early dedifferentiation and metastasis of up to 20% solid tumors.
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