Abstract
Background and aims: We aimed to determine the effects of enteral supplementation of a prebiotic mixture of neutral and acidic oligosaccharides (SCGOS/LCFOS/AOS), who are supposed to improve the development of the immune system and therefore improve the immune response to DTaP-Hib vaccinations in preterm infants.Methods: In a RCT, preterm infants with a gestational age < 32weeks and/or birth weight < 1500g received enteral supplementation of SCGOS/LCFOS/AOS or a placebo (maltodextrin) between days 3-30 of life. Serum samples were taken at 5 and 12 months of age, after the 3th and 4th vaccination respectively. Samples were analyzed by multiplex immune assay (MIA, Luminex).Results: In total, 89 preterm infants at 5 months and 85 infants at 12 months were included. Baseline patient and nutritional characteristics were not different between both groups. Results are shown in table 1. No significant differences were shown (all p>0.05).Table 1 Vaccination response of preterm infant at 5 and 12 months.Full size tableConclusions : Enteral supplementation with the prebiotic mixture of neutral and acidic oligosaccharides did not influence the immune response on vaccinations against DTaP-Hib in preterm infants.
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