Abstract
We hypothesized that the interval hazard function for distant metastasis (DM) would be biphasic due to an early wave from micrometastatic disease and a late wave from local persistence after radiotherapy (RT). There is some evidence for the late wave; local failures following radiotherapy (RT) are associated with a high rate of late distant metastasis. Since RT dose escalation has been shown to reduce biochemical failure (BF) and DM, RT dose should have the most effect on the late wave of metastasis.
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