Abstract
Neonatal T4 detected 128 cases with TBG < 5 ug/ml; 65 were followed-up; mean CA=1.1y; (M=61; F=4). In 43 cases the Z score of stature at the first and last observation were=0.08 (1.3) and 0.74 (0.9), respectively. No signs of hypothyroidism were observed. In 65 cases we found a basal T4=1.8 (0.6); free T4 (DPC)=0.5 (0.3); free T4 (BAXTER)= 1.3 (0.4); TSH= 2.9 (1.7). A TRH test (7 ug/kg) was performed in 12 cases (table 1):Ho-TBG patients showed normal growth and no sings of hypothyroidism. Free T4(DPC) suffered interference by HO-TBG state. Some increased basal values and TRH hyperresponsive pattern suggest that pituitary negative feedback could be altered in patients with Ho-TBG.t (student) test: * p<0.0005; ** p<0.005.
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