Abstract

Neurobiological evidence points to a cortical and behavioral co-development, deviations from which are posited to be associated with elevated substance use behavior in adolescents. However, it is not clear whether these deviations are neurobiological predispositions for developing substance use or if they are associated with severity of such behavior. To fill this knowledge gap, the current large-cohort longitudinal study assesses impulsivity and neural reward processing in drug-naïve adolescents who go on to develop alcohol use with varying severity 2 years later.

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