Abstract
We screened Salmonella and Escherichia coli isolates, collected 2004–2008 in the United Kingdom, for 16S rRNA methyltransferases. rmtC was identified in S. enterica serovar Virchow isolates from clinical samples and food. All isolates were clonally related and bore the rmtC gene on the bacterial chromosome. Surveillance for and research on these resistance determinants are essential.
Highlights
We screened Salmonella and Escherichia coli isolates, collected 2004–2008 in the United Kingdom, for 16S rRNA methyltransferases. rmtC was identified in S. enterica serovar Virchow isolates from clinical samples and food
Aminoglycosides are used in treating a wide range of infections caused by both gram-negative and grampositive bacteria and have been classified by the World Health Organization as critically important antimicrobial drugs in human medicine [1]
With the exceptions of armA and rmtB in porcine Escherichia coli from Spain and the People’s Republic of China, respectively [4,5], all methyltransferase genes described have been identified in human clinical samples, for which a possible role for food in transmission of these determinants remains largely unknown
Summary
We screened Salmonella and Escherichia coli isolates, collected 2004–2008 in the United Kingdom, for 16S rRNA methyltransferases. rmtC was identified in S. enterica serovar Virchow isolates from clinical samples and food. Six types of 16S rRNA methyltransferase genes conferring resistance to these antimicrobial agents, armA, rmtA, rmtB, rmtC, rmtD, and npmA, have been identified [2,3]. ArmA and rmtB are spread in enterobacteria worldwide, and the presence of other methyltransferase genes have not previously been reported in Europe [3].
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