1697TiP Evaluation of gonyautoxins (GTX) on objective and subjective symptoms of chemotherapy-induced peripheral neuropathy (CIPN)

Abstract

CIPN is a common side-effect of multiple anti-neoplastic drugs and approved treatments (Tx) with level 1 evidence are lacking. Management of this adverse event is restricted to dose reductions and Tx interruptions. GTX is a phycotoxin that reversibly binds to the receptor site on the voltage-gated sodium channel of excitable cells, inhibiting the membrane depolarization and consequently conduction of nervous impulse. Initial data indicates that the GTX (topical formulation) improves pain and sensitive symptoms related to peripheral neuropathy secondary to anti-HIV drugs.