169 Improved lung function and hepatosteatosis after oral choline substitution in CF patients

Abstract

intestinal malabsorption of both fat-soluble vitamins and nutrients. In this cross-sectional study, we tried to evaluate the nutritional status and determine the prevelance of fat-soluble vitamin deficiency in patients with cystic fibrosis (CF) in Turkey. Methods: We retrospectively analysed the data of fat-soluble vitamin levels, microbiological status, lung function tests and nutritional status of patients with CF who attend to Hacettepe University Department of Pediatric Pulmonology and Gastroenterology within three months. Results: We evaluated 130 patients; the mean age of the patients was 11.9±6.7 years and the mean duration of following time was 8.7 years. According to WHO BMI Z score, 10.7% of patients had malnutrition. The mean FEV1 was 75±26% and the mean FVC was 75±22%. Staphyloccus aureus was the most common microorganism isolated from sputum culture. Pancreatic insufficiency was detected in 99% of patients. Vitamin A and D deficiencies were the most common findings with 26% and 32% respectively in our cohort. In addition to multivitamin complex, 20% of patients were receiving extra vitamin A and 22.3% of patients were receiving extra vitamin E supplement. Conclusion: Fat-soluble vitamin testing and assessment of nutritional status are essential to identify deficiency in pancreatic-insufficient children who may be noncompliant to supplementation or require a higher supplement dose and nutritional support.