169 Endothelial Insulin Sensitisation Enhances Vascular Repair and Aortic Vasomotor Function in Systemic Insulin Resistance

Abstract

IntroductionInsulin resistance is independently associated with cardiovascular events. We have previously shown that mice haploinsufficient for the insulin receptor (IRKO) exhibit hypertension, vasomotor dysfunction and impaired endothelial regeneration after denuding...