168. Comparison between frequency of thrombophilia in patients with and without severe preeclampsia in a Brazilian Tertiary Center.

Abstract

Introduction In the last two decades studies have associated thrombophilia with the risk of developing severe preeclampsia (PE). Few of them, however, have been conducted in Latin America to assess the importance of thrombophilia in these patients. Objective Evaluate thrombophilia frequency among patients with and without severe preeclampsia in a Brazilian Tertiary Center. Methods From October 2009 to October 2015, a retrospective case-control study was conducted in pregnant women with severe PE and compared to normal pregnant women at Hospital das Clinicas, FMUSP. The patients with PE who had no gestational trophoblastic disease, foetal malformation or chromosomal abnormalities and who underwent thrombophilia screening during the postnatal period were included. Pregnant women without comorbidities and normal obstetric outcome were included to make up the normal group, and were screened for thrombophilia during prenatal care (when functional dosages were abnormal, they were repeated in the postnatal period). Factor V Leiden (FVL), G20210A prothrombin mutation (PM), antithrombin, protein C, protein S, homocysteine, lupus anticoagulant, and anticardiolipin IgG and IgM antibodies were analysed. The frequency of thrombophilia in the two groups was compared. Results We included 199 patients with severe pre-eclampsia and 50 normal pregnant women. In patients with severe PE we found 55 (27,6%) women that had at least one thrombophilia (14 Antiphospholipid Syndrome,10 heterozygous PM, 10 protein S deficiency, 9 hyperhomocysteinemia, 9 heterozygous FVL, 2 antithrombin deficiency, 4 association of thrombophilia). In the control group 2 (4%) women had positive thrombophilia research (1 heterozygous PM and 1 heterozygous FVL), p Discussion Our results show a higher rate of thrombophilia among the patients with servere PE (p