Abstract
Laboratory animal studies indicate that aging is associated with exaggerated inflammatory responses which are correlated with depressive-like behavior. One mechanism that may link increased inflammation to behavioral change in older animals is glutamate. Increased glutamate has been reported following activation of central inflammatory responses and can be toxic to both neurons and glia. To examine the impact of older age on CNS glutamate and its relationship with immune responses in humans following administration of the inflammatory cytokine interferon (IFN)-α, glutamate normalized to creatine (Glu/Cr) was measured using magnetic resonance spectroscopy (MRS) in 17 patients [8 older (age > 55 years) and 9 younger (age 55 years) and 7 younger (age
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