Abstract
Apoptosis has been thought a feature of radioresponsive malignancy. Sixty-six patients with cervical cancer & previously measured intrinsic radiosensitivity following 2 Gy of radiation (SF2 value) had measurement of the percentage of apoptotic cells (Apoptotic Index or AI). AI was recorded in ten H and E stained tumour sections with Mitotic Index (MI) and KI–67 positivity as measures of proliferation. High AI was associated with poor prognosis. Five-year survival & local control for tumours with an AI below the median was greater than for those with an AI above the median (79% versus 47% for survival, <i>P</i>=0.003; 79% versus 61% for local control, <i>P</i>=0.01). AI & SF2 were independent, but AI correlated with MI & KI–67. Patients with both an SF2 & AI value above the median did badly (25% 5-year survival, 46% local control) compared with those with values below the median (80% 5-year survival, 100% local control), AI may reflect proliferation and could be used with SF2 as a predictor of tumour response to radiotherapy.
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