167 Improvement in SHIM Scores with the iNOS Stimulator, Revactin®

Abstract

Revactin®, a mixture of three components found in nature (ginger root, muira puama and Paullinia cupana) combined with the amino acid, L-citrulline, has been shown both in vivo and in vitro to act directly on the corporal smooth muscle cells (CSMC) to upregulate the production of the inducible nitric oxide synthase (iNOS) enzyme. This results in an increase in the intracellular production of nitric oxide (NO) and cGMP which has been shown in the rat to act in an anti-apoptotic and anti-oxidative manner and, when given long-term, leads to an improvement in the CSMC to collagen ratio and an improvement in erectile function . A recently reported short-term pilot study conducted in men primarily in their 7th decade of life demonstrated that the Revactin® was not only safe but surprisingly also elicited some early improvement in their erectile function. To examine the efficacy of Revactin® on early erectile function among middle-aged men with erectile dysfunction.