Abstract
Vitamin A and its derivatives, particularly retinol, slow both chronological and photo-induced aging processes. Retinol reduces the appearance of wrinkles and the decrease of the skin firmness and elasticity by protecting against collagen and elastin fiber changes. In addition to retinol’s rejuvenating skin benefits through direct transcriptional activation, recent studies also suggest an epigenetic regulation through micro-RNAs (miRNAs) modulation. We investigated how retinol supports the stimulation of type I collagen and elastin through proteomic, transcriptomic and epigenetic miRNA- expression changes in human skin fibroblasts.
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