Abstract

Hereditary breast (BC), ovarian (OC) and pancreatic (PC) cancers are the major BRCA-associated tumours. However, some BRCA1/2-non informative patients with a strong cancer personal and/or family history need a further genetic testing through a multi-gene panel including other high- and moderate-risk susceptibility genes. In recent years, Next-Generation Sequencing has allowed to study multiple genes simultaneously, reducing analysis costs, increasing genetic data, and offering more information to patients.

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