Abstract
Background: Retinoids are the best-studied ingredients for anti-aging facial benefits. Retinoids include retinol and tretinoin. Tretinoin is a prescription retinoid with established improvement in skin thickness and fine lines, possessing poor tolerability. This has led to development of OTC retinol formulations. This research investigated the efficacy, tolerability, and consumer acceptance of a rapid retinization protocol involving escalating doses of 0.25%, 0.5% and 1.0% retinol liquids in combination with a lipid barrier treatment for 12 weeks, as compared with an escalating dose of branded tretinoin cream (0.025%, 0.05% and 0.1%) used with a dermatologist recommended moisturizing cream (benchmark control).
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