166: Perinatal outcome of women with epilepsy: Results from a population-based cohort study

Abstract

Approximately 0.5–1% of the world population has epilepsy, one third of them are women in reproductive age. The purpose of the current study was to evaluate pregnancy outcome in women with epilepsy. In a population-based cohort study, perinatal outcomes of women with and without epilepsy were compared. Deliveries occurred between the years 1991 and 2014 in a tertiary medical center. We excluded multifetal pregnancies and fetuses with congenital anomalies and chromosomal abnormality. Generalized estimation equation (GEE) models were used to control for confounders. During the study period 243,682 deliveries were included, of which 711 (0.29%) occurred in women with epilepsy. In the univariable analysis a significant association was found between maternal epilepsy and preterm delivery, cesarean delivery and low birth weight (<2500 grams; Table 1). Using GEE models, controlling for maternal age and nulliparity, maternal epilepsy was noted as an independent risk factor for preterm delivery (aOR 1.5 95%CI 1.18- 2.00, p=0.001), cesarean delivery (aOR 1.4, 95% CI 1.21- 1.79, p<0.001) and low birth-weight (aOR 1.4 95% CI 1.08- 1.88, p=0.011; Table 2). Pregnancy of women with epilepsy is independently associated with adverse perinatal outcomes including preterm delivery, cesarean delivery and low birth weight.View Large Image Figure ViewerDownload Hi-res image Download (PPT)