166-P

Abstract

Atopic diseases are related to the production of IgE to certain allergens, but the genetic control of this shift has not been clearly elucidated. atopic mite (Dermatophagoides farinae, Dermatophagoides pteronyssinus, Blomia tropicalis) has a particularly important relationship in the development of asthma in children and hypersensitivity in young adults. The main feature of the HLA system is the high degree of polymorphism and its crucial role in the immune response against unrelated agents to the host. HLA surface molecules interact with CD4 + T cells in turn to release cytokines that mediate the Th1 or Th2 response. The aim of this study is to assess the influence of HLA genes in susceptibility/resistance of individuals sensitized to mites. In this case-control study 108 patients sensitized to mites were compared with 66 individuals who did not show sensitization to mites. All samples were typed for the loci HLA-A, HLA-B, HLA-C and HLA-DRB1 by PCR-SSO (polymerase chain reaction- sequence specific oligonucleotides) by LUMINEX methods. No significant result was observed between sensitized and unsensitized individuals between the alleles of the loci HLA-A, HLA-B, HLA-C and HLA-DRB1, except HLA-C ∗ 15 that showed a negative association between patients (2.8%) and controls (15.2%), with p = 0.0051, OR = 0.16, CI = 0.03 to 0.67). In this study we suggest the involvement of HLA-C gene as a protective gene to dust mite atopic patients.