1658 EFFICACY OF IMMEDIATE POST-TUR MITOMYCIN-C (MMC) INSTILLATION IN HIGH RISK NON-MUSCLE INVASIVE BLADDER CANCER TREATED WITH BACILLUS CALMETTE-GUERIN (BCG)

Abstract

You have accessJournal of UrologyBladder Cancer: Superficial1 Apr 20111658 EFFICACY OF IMMEDIATE POST-TUR MITOMYCIN-C (MMC) INSTILLATION IN HIGH RISK NON-MUSCLE INVASIVE BLADDER CANCER TREATED WITH BACILLUS CALMETTE-GUERIN (BCG) Moon-Ki Jo, Kanghyon Song, and Jong-Wook Park Moon-Ki JoMoon-Ki Jo Seoul, Korea, Republic of More articles by this author , Kanghyon SongKanghyon Song Seoul, Korea, Republic of More articles by this author , and Jong-Wook ParkJong-Wook Park Seoul, Korea, Republic of More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.1768AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES To evaluate the efficacy of immediate post-TUR MMC instillation in high risk non-muscle invasive bladder cancer treated with BCG. METHODS From January 2000 to December 2007, 162 high risk non-muscle invasive bladder cancer patients underwent TUR and BCG instillation at our institution. Among them 76 patients received additional immediate post-TUR MMC instillation (Group A), and remaining 86 patients underwent TUR and BCG instillation only (Group B). Sixty mg of MMC was mixed with 50ml of normal saline and was instilled in bladder within 4 hours after TUR. Tice strain BCG 12.5mg was used with 6-week induction course followed by 3-week maintenance every 3 months. The recurrence rate, time to recurrence, and stage and grade at recurrence were invstigated. The mean follow-up was 33.4 months. RESULTS There were no significant differences in the characteristics of both groups, including age, sex, stage, and grade. Group A showed significantly lower recurrence rate than Group B (26.3% vs 48.8%, p=0.003). Group A showed somewhat longer time to recurrence but it was not statistically different (24.9 months vs 21.8 months, p=0.293). The change in stage and grade at recurrence were not different between 2 groups. The 5 year recurrence free survival rate was significantly higher in Group A (72% vs 42%, p=0.003). CONCLUSIONS The immediate post-TUR MMC instillation significantly reduced recurrence in high risk non-muscle invasive bladder cancer patients treated by BCG. But it did not influenced the stage and grade at recurrence. Changes in the stage and grade at recurrence MMC + BCG (Group A) BCG (Group B) p-value T stage up 10.0%(2/20) 14.3%(6/42) 0.645 unchanged 55.0%(11/20) 47.6%(20/42) down 35.0%(7/20) 38.1%(16/42) Grade up 15.0%(3/20) 23.8%(10/42) 0.434 unchanged 65.0%(13/20) 61.9%(26/42) down 20.0%(4/20) 14.3%(6/42) © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e666 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Moon-Ki Jo Seoul, Korea, Republic of More articles by this author Kanghyon Song Seoul, Korea, Republic of More articles by this author Jong-Wook Park Seoul, Korea, Republic of More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...