Abstract
Background: Aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that sense environmental stimuli. Autophagy is an intracellular disintegrative process regarding as an endogenous defense mechanism. Both AhR and autophagy participate in maintaining skin homeostasis as well as development of skin disorders. Objectives: We aimed to study the immunohistochemical expression of AhR, CYP1A1, and autophagy-related marker, microtubule-associated protein IA/IB light chain 3 (LC3) in lesional skin of psoriasis patients and to investigate the correlation between AhR and autophagy-related protein.
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