Abstract
Respiratory muscle blood flow is necessary for the delivery of adequate energy substrate to maintain required respiratory muscle work rates. Diaphragmatic blood flow (Qdi) and cardiac output (Qc) were measured in 8 newborn dogs age 4-15 days using the radionuclide-labelled microsphere method. Measurements were made during quiet breathing (QB) and CO2 rebreathing (CR) (steady state FiO2=.31±.09, FiCO2=.029±.008, mean±SEM) with and without pentobarbital sedation (5-7mg/kg). In the unsedated newborn dog, rebreathing results in increased respiratory frequency (38±7 v 53±11bpm), alveolar ventilation (VA), Qdi, and Qc. Although VA increased during sedated rebreathing, Qdi and Qc were unchanged. Thus the cardiovascular response to increased ventilation produced by CO2 rebreathing is adversely affected by pentobarbital sedation, suggesting that sedation may impair respiratory muscle endurance.
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