164-POS

Abstract

Objectives The aim of this study is to investigate the decrease of circulating EPCs in the maternal circulation during pregnancy related to the development of preeclampsia. Methods This is an analytical observational study with a cohort design (a follow-up prospective study) during May 2012 to March 2013. It involved 60 primigravid women of Malang region, before her 20 weeks of gestation, followed up at 24–32 weeks of gestation and again after 34 weeks of gestation, while venous blood sample was collected. The expression of EPCs was isolated by the specific antigen marker CD34+ and calculated by flow cytometry. All subjects were followed up for the clinical and laboratory criteria of preeclampsia or the normotensive state until delivery. Analysis of collected data was conducted by an independent t-test and one way ANOVA. Results We found 9 subjects that developed preeclampsia from a total of 25 subjects analyzed in this study. The decreased expression of maternal circulating EPCs was significantly related to the development of preeclampsia at 24–32 weeks of gestation (mean 119.67) until after 34 weeks of gestation (mean 72.67) with a p-value of Conclusions There was a significant decrease in the expression of maternal circulating EPCs from 24 weeks of gestation which was statistically related to the development of preeclampsia. A further research study with a larger subject cohort and more detailed screening procedures should be carried out, related to the many factors affecting the mobilization of EPCs in the maternal circulation. Disclosures N.G. Prabawati: None. N. Prasetyorini: None.