163. Efficacy of a novel non-invasive indicator of arteriosclerosis for the prediction of hypertensive disorder of pregnancy

Abstract

Introduction Prediction of the onset of hypertensive disorder of pregnancy (HDP) has been burden for the obstetrician. Arterial velocity pulse Index (AVI) which reflects systemic hemodynamic status and arterial pressure volume Index (API) which reflects brachial artery stiffness are effective for accessing risks of adult cardiovascular disease because they are simply evaluated by an arm-cuff monitor and indicate a future risk for arteriosclerosis. However, the efficacy of AVI and API for pregnant woman remains unknown. The aim of the present study is to preliminarily examine distributions of AVI and API during pregnancy and assess the involvement of AVI and API in HDP. Methods AVI and API of pregnant women who visit to the outpatient unit of Kumamoto University Hospital between 2015 and 2017 were examined using PASESA®AVE-1500 (Shisei Datum, Tokyo, Japan). All pregnant outcomes were prospectively reviewed after the measurement of AVI and API and were thereafter classified into HDP group and non-HDP group with or without a diagnosis of HDP. Spearman tests and Student t tests were used for statistical analysis. Results Outcomes of a total of 144 pregnant women were identified. The mean age of the women was 32.9 ± 5.0 years old (20–42 years old). AVI and API were assessed at 32 ± 8 weeks of gestation (ranges; 10–42 weeks). There was negative correlation between API and weeks of gestation, whereas AVI was not corelated with the gestational weeks. Twelve women (8.3%) developed HDP. The mean AVI in HDP group was not different with that in non–HDP group (15.2 ± 3.2 vs 14.4 ± 2.8, P = 0.49). The mean API in HDP group was significantly higher than that in non-HDP group (29.0 ± 8.0 vs 23.5 ± 5.7, P Conclusion This is a first report to examine the range of AVI and API in pregnant women. Evaluation of API during pregnancy may worth to predict of the onset of HDP.