16232 Analysis of androgen excess and association with polycystic ovary syndrome in female-pattern hair loss before 30 years of age

Abstract

Pathogenesis of female-pattern hair loss (FPHL) is known to be related with androgen, but its role in the FPHL is not fully understood. Polycystic ovarian syndrome (PCOS) is the most common androgen excess disorder in women. Based on the pathophysiologic commonality, there can be meaningful assiociation of these two disease, and it can be helpful to understand the role of androgen in FPHL We investigated this study to identify the characteristics of young FPHL in regard to androgenic traits and connection with PCOS. We reviewed the clinical features, laboratory data, ultrasonographic features of ovary, and trichoscopic findings in mid-frontal area in FPHL subjects under 30 years old. A total of 50 female patients were enrolled. The mean age of the patients was 21.5 years old. Most subjects (30/50, 60%) were satisfied with Rotterdam criteria of PCOS. A fifth of subjects (11/50, 22%) showed hyperandrogenism signs of acne or hirsutism in addition to FPHL. The ratio of abnormal value (50.0%, n = 30) in antimüllerian hormone (AMH) was higher than that of total testosterone (22.0%, n = 50) and DHEA-S (20.0%, n = 50). All of hormones showed more proportion of abnormality in FPHL with PCOS than FPHL without PCOS patients. In FPHL patients under 30 years old, it is likely that PCOS was prevalent. So overall clinical, biochemical, and sonographic evaluation should be conducted to examine the presence of PCOS. AMH may be more helpful in detecting FPHL compared with classic androgens for its higher abnormality ratio.