16184 Risk stratification of severely dysplastic nevi with the use of noninvasively obtained gene expression and mutation analyses

Abstract

Rule-out strategies to noninvasively detect cutaneous melanoma generally focus on differentiating melanoma from nonmelanoma lesions. However, given the variabilities in practice and lack of guidelines, it is important to understand how such technologies perform on borderline lesions of uncertain clinical behavior. Data from 103 eligible skin lesions clinically suspicious for melanoma were noninvasively sampled via adhesive patches to enable genomic analyses. The same lesions were surgically biopsied immediately afterward to enable comparisons with histopathologic diagnoses rendered by a panel of three dermatopathologists.