Abstract
Darier disease (DD) is a rare autosomal dominant genodermatosis, which main feature is the hyperkeratotic papule, mainly in seborrheic areas. Studies with systemic retinoids show efficacy in disseminated DD, but there are no large studies on the effects and safety of long-term treatment in these patients. We performed a retrospective study with 32 patients with DD from the University of São Paulo Medical School, during a period of 10 years, from 2007 to 2017. Out of 32 patients, 18 were treated with systemic retinoids (56.2%).
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