Abstract
Conclusions: The study results reveal a significant relationship between normalized GAGs and BMI in this population of osteoarthritic patients. Higher patient BMI (>30 kg/m2) may be similar to dynamic compression injuries that cause increased GAG synthesis in response to cartilage damage. The lack of significance at day 5 and 13 may be the result of OA tissue variability and significance may be achieved with increased sample numbers. In conclusion, elevated normalized GAGs in obese patients’ chondrocytes suggests increased cartilage damage.
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